The tower is one of the four blocks comprising a total of 1508 apartments and penthouses to be built at Owen Street.
The scheme will also include lounges, a roof garden, a swimming pool, an indoor tennis court, a fully equipped gymnasium, business facilities, a 24/7 basement parking, and a cinema.
The tallest building will be 200.5m-tall, while the other three will be 157.9, 122 and 140.4m-tall, respectively.
Andy Finch, head of sales at Renaker Build, said: “We are thrilled to have received permission for our latest development which will be the first within the Great Jackson Street framework, creating a new community at the southern gateway to the core of Manchester city centre.
“We are fully committed to the redevelopment of the wider Great Jackson Street area and further regeneration and development will follow alongside our Owen Street scheme. This development has been designed with a wide range of apartment types, the vast majority of which are significantly more generous than purchasers will find elsewhere in the city.
“With the larger unit sizes, a high-end specification and residents’ amenities that are genuinely unmatched anywhere else in Manchester, this will undoubtedly become the new destination of choice for city centre residents.”